Journal of the American College of Cardiology. 4,11 … nodular hyperplasia / benign prostatic hyperplasia: Stromal neoplasms that involve only the prostate are divided into stromal tumor of uncertain malignant potential (STUMP), stromal sarcoma and carcinosarcoma, STUMP, prior to 1998, was termed atypical stromal hyperplasia (, Rare prostatic tumors with stromal degenerative atypia featuring vacuolated nuclei, May recur rapidly after resection; rarely progress to stromal sarcoma, STUMP occurs in a broad age range with median age of 58 years (, Usually presents with urinary obstruction, followed by hematuria, hematospermia and rectal fullness, Many STUMPs are incidental findings and behave indolently, A minority recur after surgery or metastasize, Up to 46% reportedly recur without definitive surgery (, Microscopically, STUMP should have rare to no mitotic activity and lack necrosis, Atypical stromal cells insinuate between benign acini, CD34 and cytokeratin are the most helpful immunostains, 34 year old man with prostatic stromal tumor with fatal outcome (, 56 year old man with recurrent prostatic stromal tumour of uncertain malignant potential (, 67 year old man with incidental prostatic stromal tumor of uncertain malignant potential (, Four patterns of STUMP have been described (, Hypercellular stroma with scattered degenerative atypia featuring vacuolated nuclei and smudged chromatin (50% of cases) (, Hypercellular stroma with bland spindle stromal cells, Benign phyllodes-like, similar to breast, with "leaf like" growth of hypocellular fibrous stroma surfaced by benign prostate epithelium, Myxoid stroma with bland cells, lacking the nodularity seen in benign hyperplasia (, STUMP may also have epithelial proliferations which mask its diagnosis: most commonly glandular crowding, prominent basal cell layer, prominent papillary infolding (, STUMP arises from specialized, hormonally responsive prostatic stromal cells, thus hormonal receptor immunostains may be positive. 1. ... p16 staining pattern. Grossly, they are circumscribed with a whitish-gray appearance. Follicular dendritic cell sarcoma (FDCS) is extremely rare and underdiagnosed, occurring primarily in lymph tissue and uncommonly in extranodal sites such as the spleen, liver, and tonsils [].Metastatic disease has also occurred, especially when the site of origination is the liver, affecting distant sites such as the lung and gastrointestinal system []. : Semester: FORESTRY Program: G. STONE Author: SEPTEMBER, 1992 NOVEMBER, 1991 Date: Previous Outline Dated: APPROVED: -----2-FOREST PATHOLOGY FOR 114-3 \. had cancer in other Fifty-one atypical leiomyomas with available glass slides and clinical follow-up data were identified. In this article, learn about the types, diagnosis, and when to see a doctor to check for melanoma. From Libre Pathology. Definition / general. Objective: This retrospective study was designed to evaluate the clinicopathologic features and outcomes of a cohort of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP) seen at a single institution. WebPathology is a free educational resource with 10925 high quality pathology images of benign and malignant neoplasms and related entities. Clinical presentation The patient presents with a focal area of pain and tenderness to palpation. Inst. Jump to navigation Jump to search. Digital pathology and image analysis are also producing new insights, providing quantitative justification of many existing diagnostic criteria while challenging others. Axonal regrowth was observed as early as 3 DPA and signs of unorganized axonal growth and neuroma formation were evident by 28 DPA. The Electronic Sarcoma Update Newsletter (ESUN) is an online peer-reviewed newsletter that contains articles of interest to sarcoma patients and their caregivers, physicians, and nurses.ESUN has an outstanding Medical Advisory and Editorial Board and is a vital source of information for thousands of readers worldwide. Pre-pouchitis. " Stanford CA 94305-5342 . Malignant Potential (STUMP): Review of Pathophysiology, Classification, Diagnosis, Treatment, and Surveillance Abstract Uterine smooth muscle tumors of uncertain malignant potential (STUMP) represent a group of rare and challenging leiomyoma neoplasms. in skin it is called dermatofibroma (fibroma simplex or nodulus cutaneous). Knowledge of these tumors continues to evolve as information emerges about pathology, molecular genetics, and recurrence … The Von Kossa silver stain highlights the calcium salts (black). STUMP is diagnosed when atypical histologic features are found that range between leiomyoma and leiomyosarcoma . Pouchitis. spp.) The term smooth uterine muscle of uncertain malignant potential (STUMPs) indicates a group of uterine smooth muscle tumors (SMTs) that cannot be diagnosed unequivocally as benign or malignant. Spitzoid tumour of uncertain significance, atypical Spitz naevus, Spitzoid melanoma. 2. Knowledge of these tumors continues to evolve as information emerges about pathology, molecular genetics, and recurrence rates. The hard fibroma (fibroma durum) consists of many fibres and few cells, e.g. Active pouchitis." Spitz naevus may pose great diagnostic difficulty due to clinical, dermatoscopic and histologic features resembling melanoma.Though usually seen in children, Spitz naevi may arise in adults. what is the pathology?" Andrea Dall’Asta 1, Salvatore Gizzo 2, Andrea Musarò 1, Michela Quaranta³, Marco Noventa 2, Costanza . That occurs in response to injury, such as injections for dental surgery David Klingman, DMD, of... 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